FIG 9.

Working model for ezrin and DDX3 functions. The model demonstrates a novel role for ezrin in regulating transcription and translation independently of its membrane-localized open conformation. We propose that ezrin and DDX3 are the components of an mRNP complex associated with translation initiation machinery and stress granule aggregates. In this model, ezrin functions as a regulator of mRNP homeostasis required for transitions between translationally active (translation initiation complex) and inactive (stress granule) states under normal or oncogenic/stress conditions.