Table 2.

Physiologic parameters of the in silico cell used for the rate equation simulations.

Additional flux definitions of the full rate equation model
Sodium-Ca2+ exchanger mediated flux		$J_{\text{NaCa}}=p_{\mathrm{5}}\frac{\text{C}{\text{a}}_m}{\text{C}{\text{a}}_m+p_{\mathrm{6}}}\frac{p_{\mathrm{7}}^{\mathrm{2}}}{p_{\mathrm{8}}^{\mathrm{2}}+\text{C}{\text{a}}_c^{\mathrm{2}}}$
Mitochondrial unitransporter mediated flux		$J_{\text{uni}}=p_{\mathrm{9}}\frac{\text{C}{\text{a}}_c^{\mathrm{2}}}{p_{\mathrm{10}}^{\mathrm{2}}+\text{C}{\text{a}}_c^{\mathrm{2}}}$
Effective mitochondrial flux		J mito = J NaCa − J uni
Leak flux through ER membrane		J leak = p 11(Caer − Cac)
Influx from external space		J ext = J ext,bas − (p 12Caer + p 13Cac)
PMCA mediated flux		$J_{\text{pmca}}=p_{\mathrm{14}}\frac{\text{C}{\text{a}}_c^{\mathrm{2}}}{p_{\mathrm{15}}^{\mathrm{2}}+\text{C}{\text{a}}_c^{\mathrm{2}}}$
Parameter values for the rate equation calcium model
Pr = 0.03 ms−1	p1 = 0.5 μM	p2 = 0.9 μM	p3 = 1.3 μM
p4 = 0.2 μM	Pp = 0.06 μM ms−1	p5 = 10 μM ms−1	p6 = 0.6 μM
p7= 1 μM	p8 = 10 μM	p9 = 0.2 μM ms−1	p10 = 1 μM
p11 = 10−3 ms−1	p12 = 3 · 10−6 ms−1	p13 = 15 · 10−6 ms−1	p14 = 0.01 μM ms−1
p15 = 0.7 μM	IP3 = 0.4 μM	fcyt = 0.015	fer = 0.5
Jext,bas = 3.5 · 10−3  μM ms−1	Δ = 0.07	γ −1 = 30