Figure 2.

Astrocytic activity is necessary for motor skill learning. (a) Motor skill learning curves for saline and FC injected mice. Two-way ANOVA revealed a significant effect with training (P = 0.0001) and treatment (P < 0.0001). FC injected mice show a deficit in motor skill learning that is rescued by D-serine on days 6 and 7. (b) No difference was detected between number of reaching attempts made on day 1 and day 5 with FC injection. (c) Representative images of dendritic spines in saline and FC injected conditions. Scale bar: 3 μm. FC injection does not alter the dendrite width and spine density. ^* P < 0.05 and ^** P < 0.01.