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. Author manuscript; available in PMC: 2016 Feb 11.
Published in final edited form as: Sci Signal. 2015 Aug 11;8(389):ra80. doi: 10.1126/scisignal.aab1624

Fig. 1. Survivin targeting impairs mitochondrial metabolism.

Fig. 1

(A–F) Global metabolomics screening of PC3 cells transfected with control or survivin-directed (SVV) siRNA (n=5 biological replicates; see also table S1). Changes in the concentrations of metabolites implicated in oxidative phosphorylation (A and B), fatty acid β oxidation (C and D), or glutathione metabolism (E and F) are shown. For the heatmap (D), red indicates increased concentration; green indicates decreased concentration. Only significant changes (p<0.05) are shown. For box plots (B and F), relative metabolite abundance is represented. The limit of upper and lower quartiles, median values (straight line), and maximum and minimum distribution are shown. Cross, mean value; circle, extreme data point.