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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Jul 17;25(18):3956–3960. doi: 10.1016/j.bmcl.2015.07.031

Scheme 1.

Scheme 1

Synthesis of the N-phenylpicolinamide derivatives.

Reagents and conditions: (a) for carboxylic acids, EDC.HCl, HOBt.H2O, DIPEA, dioxane; (b) for carboxylic acids, 1. thionyl chloride, benzene, reflux for 2 h; 2. TEA, THF, 40 °C, 1 h; (c) for acid chloride, DIPEA, CH2Cl2, 4h.