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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Jul 17;25(18):3956–3960. doi: 10.1016/j.bmcl.2015.07.031

Scheme 3.

Scheme 3

Synthesis of the N-(3-fluoromethoxyphenyl)picolinamides 23 – 25.

Reagents and conditions: (a) Ag(OTs), MeCN, reflux, overnight; (b) CsF, HO(CH2O)6H, reflux, 3.5 h; (c) N-(4-R-3-hydroxyphenyl)picolinamide, K2CO3, 40–50 °C, 3 days.