Table 1.

SAR of N-phenylpicolinamide derivatives.

Compd	R1	R2	MW	CLogP	tPSA	Affinity IC50 (nM)	Log(IC50 ± SE)
2	H		262.69	2.80	50.69	5.1	−8.29 ± 0.09
3	H		264.23	2.67	50.69	4.6	−8.34 ± 0.08
10	H		246.24	2.26	50.69	31.6	−7.50 ± 0.09
11	H		307.15	2.95	50.69	322	−6.49 ± 0.08
12	H		354.15	3.16	50.69	146	−6.84 ± 0.10
13	H		228.25	2.22	50.69	13.7	−7.86 ± 0.10
14	H		244.31	2.81	41.46	4.9	−8.31 ± 0.07
15	F		280.68	2.96	50.69	7.3	−8.13 ± 0.11
16	F		282.22	2.85	50.69	6.7	−8.18 ± 0.10
17	F		264.23	2.42	50.69	89.2	−7.05 ± 0.10
18	H		223.23	1.89	65.25	10.4	−7.98 ± 0.05
19	H		241.23	2.06	65.25	7.4	−8.13 ± 0.04
20	H		257.68	2.50	65.25	5.3	−8.28 ± 0.04
21	H		302.13	2.78	65.25	47	−7.33 ± 0.08
22	H		349.13	3.04	65.25	172	−6.77 ± 0.08
23	H		280.68	2.97	50.69	3.2	−8.49 ± 0.07
24	H		282.70	2.97	50.69	3.2	−8.49 ± 0.11
25	H		248.25	2.39	50.69	3.7	−8.43 ± 0.03