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. 2015 Aug 18;6:825. doi: 10.3389/fmicb.2015.00825

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Copyright © 2015 Rios-Covian, Sánchez, Salazar, Martínez, Redruello, Gueimonde and de los Reyes-Gavilán.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the main metabolic pathways affected by the availability of carbohydrates added to the culture medium (glucose, EPS E44, and EPS R1) during growth of B. fragilis. Production ratios of enzymes catalyzing different steps in the presence of EPS with respect to glucose are indicated by cylindrical bars. Fold changes in the expression of genes in the presence of EPS with respect to glucose are indicated by rectangular bars. Black bars, glucose; dark gray bars, EPS E44; light gray bars, EPS R1. Ratios greater than sevenfold are shown with a height break. Enzymes: (1) pyruvate phosphate dikinase, (2) PEP carboxykinase, (3) pyruvate carboxylase, (4) malate dehydrogenase, (5) methyl-malonylCoA mutase, (6) diaminopimelate dehydrogenase, (7) acetolactate synthase, (8) ketol-acid reductoisomerase, (9) transketolase, (10) NADPH-dependent glutamate dehydrogenase. 2KG, 2-oxoglutarate; Glu, glutamate; PEP, phosphoenolpyruvate.