Table 2.

Association of rs9642880 (T) on 8q24.21 and rs710521 (A) on 3q28 with UBC

Study population (N cases/N controls)	rs9642880 T					rs710521 A
	Frequency		OR	95% CI	P value	Frequency		OR	95% CI	P value
	Cases	Controls				Cases	Controls
Discovery groups (GWA)
Iceland (523/32,458) a	0.53	0.48	1.21	1.07–1.37	3.10x10−3	0.76	0.72	1.23	1.07–1.42	4.32x10−3
The Netherlands (1,269/1,824) a	0.53	0.48	1.22	1.10–1.36	2.53x10−4	0.76	0.72	1.24	1.10–1.40	4.87x10−4
Follow up groups
UK (695/507)	0.49	0.45	1.21	1.03–1.42	0.021	0.75	0.72	1.14	0.95–1.37	0.147
Italy-Torino (323/381)	0.50	0.41	1.43	1.16–1.77	8.69x10−4	0.76	0.75	1.04	0.82–1.33	0.747
Italy-Brescia (174/183)	0.44	0.41	1.13	0.84–1.52	0.419	0.74	0.69	1.23	0.89–1.69	0.207
Belgium (195/372)	0.49	0.45	1.15	0.90–1.46	0.254	0.79	0.73	1.34	1.00–1.79	0.048
Eastern Europe (186/515)	0.52	0.44	1.40	1.10–1.78	5.72x10−3	0.78	0.75	1.13	0.85–1.49	0.401
Sweden (319/909)	0.51	0.48	1.16	0.96–1.40	0.116	0.79	0.75	1.27	1.03–1.57	0.026
Spain (171/836)	0.48	0.45	1.11	0.88–1.40	0.375	0.73	0.74	0.96	0.73–1.27	0.773
GWA (1,792/34,282) b		0.48	1.21	1.12–1.31	2.72x10−6		0.72	1.23	1.13–1.35	7.10x10−6
Follow up groups (2,063/3,703) b		0.44	1.22	1.13–1.33	7.98x10−7		0.73	1.15	1.05–1.26	2.80x10−3
All combined (3,855/37,985) b		0.45	1.22	1.15–1.29	9.34x10−12		0.73	1.19	1.12–1.27	1.15x10−7

All P values shown are two-sided. Shown are the corresponding numbers of cases and controls (N), allelic frequencies of variants in affected and control individuals, the allelic odds-ratio (OR) with P values based on the multiplicative model.

^aResults presented for Iceland and the Netherlands were individually adjusted by the method of genomic control (see Supplementary Methods).

^bFor the combined study populations, the reported control frequency was the average, unweighted control frequency of the individual populations, while the OR and the P value were estimated using the Mantel-Haenszel model.