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. 2015 Aug 18;5:13241. doi: 10.1038/srep13241

Figure 6. The effect of OLA1-KD on metastasis in orthotopic breast cancer models.

Figure 6

(A) BLI of female SCID mice bearing MDA-MB-231 (D3H2LN) tumors in their mammary fat pads. Representative images of animals were taken on 30th day after inoculation. Signals from the axillary/brachial regions indicate LN metastasis. The primary tumors were shielded due to their overwhelming brightness. (B) Histologic analysis of the primary tumors, LNs, and lungs dissected from the shCTL and shOLA1 groups. The arrows indicate the presence of tumor cells at LN and lung. Bottom: summaries of remote site metastasis as assessed by BLI and histopathology.