Table 2.
Comparison of baseline characteristics among ESA responders, acute hyporesponders, and chronic hyporesponders: continuous variables
| Chronic hyporesponders (n = 3086) | Acute hyporesponders (n = 6632) | ESA responders (n = 81,504) | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Median | Mean | SD | Median | Mean | SD | Median | ||
| Age (years) | 58.8 | 14.8 | 59.3 | 60.1 | 14.8 | 61.0 | 62.4 | 14.7 | 63.1 | <.0001 |
| Vintage (years) | 4.1 | 3.9 | 3.1 | 3.8 | 3.8 | 2.8 | 3.9 | 3.8 | 2.9 | <.0001 |
| BMI (kg/m2) | 29.1 | 8.4 | 27.1 | 28.2 | 7.6 | 26.6 | 28.2 | 7.2 | 26.8 | .0003 |
| Hb (g/dL) | 9.5 | 1.0 | 9.6 | 9.8 | 0.9 | 9.8 | 11.0 | 1.0 | 11.0 | <.0001 |
| Ferritin (ng/mL) | 834 | 671 | 748 | 773 | 471 | 731 | 776 | 409 | 757 | <.0001 |
| TSAT (%) | 29.0 | 16.7 | 25.0 | 29.1 | 16.5 | 25 | 31.8 | 13.6 | 29.0 | <.0001 |
| Albumin (g/dL) | 3.8 | 0.5 | 3.8 | 3.8 | 0.5 | 3.9 | 4.0 | 0.4 | 4.0 | <.0001 |
| Phosphorus (mg/dL) | 5.3 | 1.5 | 5.1 | 5.1 | 1.5 | 5.0 | 5.1 | 1.4 | 4.9 | <.0001 |
| Calcium (mg/dL) | 9.1 | 0.7 | 9.1 | 9.1 | 0.7 | 9.1 | 9.1 | 0.6 | 9.1 | <.0001 |
| PTH (pg/mL) | 561 | 662 | 387 | 494 | 478 | 374 | 442 | 371 | 354 | <.0001 |
| CRP (mg/L) | 5.8 | 3.9 | 5.4 | 6.5 | 7.8 | 3.3 | 2.9 | 5.6 | 0.9 | .0157 |
| Charlson Comorbidity Index | 5.2 | 2.0 | 5.0 | 5.3 | 1.9 | 5.0 | 5.5 | 1.9 | 6 | <.0001 |
BMI body mass index, CRP C-reactive protein, ESA, erythropoietin-stimulating agent, Hb hemoglobin, PTH parathyroid hormone, SD standard deviation, TSAT transferrin saturation
P values represent a Kruskal Wallis one way analysis of variance test