Table 3.
Chronic hyporesponders (n = 3086) | Acute hyporesponders (n = 6632) | ESA responders (n = 81,504) | p-value | ||||
---|---|---|---|---|---|---|---|
N | % | N | % | N | % | ||
Gender female | 1633 | 52.9 | 3395 | 51.2 | 44,700 | 54.8 | <0.0001 |
Race/ethnicity | <0.0001 | ||||||
American Indian | 25 | 0.8 | 68 | 1.0 | 1153 | 1.4 | |
Asian | 94 | 3.1 | 237 | 3.6 | 3063 | 3.8 | |
Black | 1339 | 43.4 | 2806 | 42.3 | 30,309 | 37.2 | |
Hispanic | 342 | 11.1 | 961 | 14.5 | 15,162 | 18.6 | |
Pacific Islander | 25 | 0.8 | 49 | 0.7 | 708 | 0.9 | |
Other | 204 | 6.6 | 432 | 6.5 | 4222 | 5.2 | |
White | 1057 | 34.3 | 2079 | 31.4 | 26,887 | 33.0 | |
Primary cause renal disease | <0.0001 | ||||||
Diabetes | 1182 | 38.0 | 2769 | 41.8 | 35,969 | 44.1 | |
Hypertension | 901 | 29.2 | 1981 | 29.9 | 24,936 | 30.6 | |
Vascular access | <0.0001 | ||||||
Fistula | 1726 | 55.9 | 3732 | 56.3 | 53,200 | 65.3 | |
Catheter | 671 | 21.7 | 1579 | 23.8 | 11,382 | 14.0 | |
Graft | 685 | 22.2 | 1321 | 19.9 | 16,904 | 20.7 | |
Other | 4 | 0.1 | 0 | 0 | 17 | 0.02 | |
Diabetes | 1558 | 50.5 | 3389 | 51.1 | 43,279 | 53.1 | 0.0001 |
Hypertension | 1114 | 36.1 | 2401 | 36.2 | 28,282 | 34.7 | 0.0174 |
Cardiac arrest | 3 | 0.1 | 7 | 0.1 | 82 | 0.1 | 0.9929 |
Myocardial infarction | 9 | 0.3 | 13 | 0.2 | 163 | 0.2 | 0.1776 |
COPD | 160 | 5.2 | 298 | 4.5 | 3097 | 3.8 | <0.0001 |
History of GI bleed | 68 | 2.2 | 73 | 1.1 | 815 | 1.0 | <0.0001 |
Liver disease | 71 | 2.3 | 126 | 1.9 | 1304 | 1.6 | 0.0009 |
HIV/AIDS | 28 | 0.9 | 53 | 0.8 | 326 | 0.4 | <0.0001 |
Hepatitis B | 22 | 0.7 | 27 | 0.4 | 245 | 0.3 | <0.0001 |
Septicemia | 241 | 7.8 | 484 | 7.3 | 4646 | 5.7 | <0.0001 |
Pneumonia | 108 | 3.5 | 206 | 3.1 | 1875 | 2.3 | <0.0001 |
Anemia hemolytic/sickle cell | 68 | 2.2 | 33 | 0.5 | 245 | 0.3 | <0.0001 |
Myelodysplastic syndrome | 40 | 1.3 | 27 | 0.4 | 82 | 0.1 | <0.0001 |
Monoclonal gammopathy | 22 | 0.7 | 33 | 0.5 | 326 | 0.4 | 0.0006 |
COPD chronic obstructive pulmonary disorder, ESA erythropoietin-stimulating agent, GI gastrointestinal, HIV/AIDS Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
P-values represent a chi square test