Table 3. Sensitivity, Specificity and Youden Index of PIVKA-II and AFP in HCC Cases From Controls at Different Times of Currently Used Cutoff Values a,b,c.
| Times of Cut-Off c | 1/2 | 1 | 2 | 2.5 | 5 | 10 | 25 |
|---|---|---|---|---|---|---|---|
| PIVKA-II | |||||||
| Sensitivity, % | 84.4 | 74.6 | 65.9 | 64.4 | 64.2 | 57.0 | 49.6 |
| Specificity, % | 21.4 | 68.6 | 84.0 | 85.2 | 90.8 | 92.9 | 94.9 |
| Youden index | 0.058 | 0.432 | 0.499 | 0.496 | 0.550 | 0.499 | 0.445 |
| AFP | |||||||
| Sensitivity, % | 80.7 | 76.1 | 72.6 | 67.4 | 66.7 | 60.0 | 48.9 |
| Specificity, % | 61.0 | 65.7 | 70.9 | 79.5 | 81.8 | 88.9 | 94.3 |
| Youden index | 0.417 | 0.418 | 0.435 | 0.469 | 0.485 | 0.489 | 0.432 |
a Abbreviations: AFP, Alpha-fetoprotein; and PIVKA-II, Protein Induced by Vitamin K Absence or Antagonist-II.
b The cut-off value for PIVKA-II is 40 mAU/mL and for AFP is 20 ng/mL.
c PIVKA-II is measured in mAU/mL and AFP in ng/mL.