Table 3.
Prevalence of Healthcare Visits and Symptoms During Human Bocavirus 1 (HBoV-1) Primary and Recurrent Events, Compared With Matched Control Periods
| Variable | HBoV-1 Primary Event |
HBoV-1 Primary Events, Peak Viral Load ≥6 Logs Only |
HBoV-1 Recurrent Event |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HBoV-1 Event, No. (%) (n= 66)a | Control Period, No. (%) (n = 132)a | OR (95% CI)b | HBoV-1 High Copy Event, No. (%) (n = 36) | Control Period, No. (%) (n = 72)a | OR (95% CI)b | First HBoV-1 Recurrence, n (%) (n = 33) | Control Period,a No. (%) (n = 66) | OR (95% CI)b | |
| Healthcare visit | 12 (18) | 11 (8) | 2.8 (1.02–7.7) | 10 (28) | 5 (7) | 7.5 (1.6–34.8) | 5 (15) | 9 (14) | 1 (.3–3.5) |
| Fever | 17 (26) | 20 (15) | 2.1 (.9–4.6) | 14 (39) | 14 (20) | 2.5 (1.0–6.1) | 9 (27) | 9 (14) | 3.0 (.9–10.4) |
| New rhinorrhea | 31 (47) | 44 (33) | 1.7 (.9–3.2) | 23 (64) | 24 (34) | 2.9 (1.3–6.7) | 13 (39) | 22 (34) | 0.9 (.4–2.4) |
| New cough | 29 (44) | 32 (24) | 2.7 (1.4–5.5) | 20 (56) | 17 (24) | 4.1 (1.6–10.7) | 15 (45) | 26 (41) | 1.6 (.6–4.2) |
| Vomiting | 3 (5) | 12 (9) | 0.5 (.1–1.7) | 2 (6) | 9 (13) | 0.4 (.08–1.9) | 1 (3) | 5 (8) | 0.3 (.04–3.4) |
| Diarrhea | 4 (6) | 9 (7) | 0.8 (.2–3.2) | 3 (8) | 7 (10) | 0.7 (.1–3.7) | 3 (9) | 6 (9) | 1.0 (.2–6.4) |
| General rash | 3 (5) | 5 (4) | 1.2 (.3–5.0) | 1 (3) | 3 (4) | 0.7 (.07–6.4) | 2 (6) | 4 (6) | 1.0 (.2–6.4) |
| Local rash | 1 (2) | 2 (2) | 1.0 (.09–11.0) | 1 (3) | 1 (1) | 2.0 (.1–32.0) | 1 (3) | 2 (3) | 1.0 (.1–11.0) |
| Fussiness | 25 (38) | 44 (33) | 1.2 (.6–2.5) | 17 (47) | 22 (31) | 2.0 (.9–4.8) | 12 (36) | 23 (36) | 1.0 (.4–2.7) |
| New respiratory symptomc | 41 (62) | 54 (41) | 2.3 (1.2–4.2) | 30 (83) | 29 (41) | 5.6 (2.1–15.1) | 20 (61) | 38 (59) | 1.0 (.4–2.5) |
Abbreviations: CI, confidence interval; OR, odds ratio.
a Symptom data missing for 2 of 132 control periods, 2 of 72 high-copy control periods, 2 of 66 recurrence control periods, and 1 of 66 primary case events. The valid percentage is reported.
b The OR was calculated using conditional logistic regression, to account for correlation in case and control periods matched by individual child.
c Defined as new-onset cough and/or new-onset rhinorrhea.