Figure 2.

Expected heterozygosity in microsatellite loci flanking the genes encoding Plasmodium falciparum dihydrofolate reductase (DHFR)–thymidylate synthase pfdhfr-ts (A) and dihydropteroate synthase (DHPS) (pfdhps; B). Samples with missing data were excluded. Error bars represent ±1 SD. Dashed lines represent average genomic level expected heterozygosity, based on unlinked loci. The single asterisks indicate a significant difference between 2 periods. The double asterisk indicates a significant difference between all 3 periods, based on permutation. P values of <.05 were considered statistically significant. Abbreviation: SP, sulfadoxine-pyrimethamine.