Table 2.

Rates of deep vein thrombosis in critically ill patients with thromboprophylaxis

Author (Year)	Study design	Population	DVT screening method	Thromboprophylaxis	Number of patients	DVT (%)
Ibrahim et al. 2002 [10]	Prospective study	Medical ICU patients; MV >7 days	Serial CUS (weekly)	Twice daily SC UFH 5,000 UI	110	23.6
Cook et al. 2005 [9]	Prospective study	Medical-surgical ICU	CUS 48 hours after admission, twice weekly and in case of clinical suspicion	Twice daily SC UFH 5,000 UI	261	9.6
PROTECT 2011 [8]	Blinded RCT	Medical-surgical ICU	CUS 48 hours after admission, twice weekly and in case of clinical suspicion	SC UFH 5,000 UI/dalteparin 5,000 UI plus placebo	3,764	5.4

CUS compression ultrasonography; DVT deep vein thrombosis; MV mechanical ventilation; RCT randomized clinical trial; SC subcutaneous; UFH unfractionated heparin