Table 1.

Univariate associations with early (within 1 h) appropriate antibiotic therapy and with early therapy with bolus volume over 20 ml/kg in children with sepsis and septic shock, respectively

Variable	Abx 0–1 h	Abx >1 h	P value	≤20 ml/kg in 2 h	>20 ml/kg in 2 h	P value
Number	20	59		26	18
Age	69 (60)	79 (66)	0.56	56 (52)	120 (62)	0.001
PRISM	15 (7)	11 (7)	0.03	11 (7)	17 (8)	0.006
PELOD	15 (8)	17 (10)	0.44	16 (9)	21 (12)	0.090
Severe underlying disease	11/20 (55 %)	28/59 (47 %)	0.61	15/26 (58 %)	9/18 (50 %)	0.76
ΔPELOD	3.4 (8.4)	6.0 (11.6)	0.35	3.2 (12.7)	10.0 (9.9)	0.067
Ventilator days	10.4 (9.2)	7.1 (8.9)	0.17	6.5 (4.8)	9.1 (7.8)	0.18
PICU days	19.5 (21.2)	10.2 (10.1)	0.01	10.7 (7.4)	17.2 (22.4)	0.17

Comparisons were performed using the t test for independent samples, and Fisher’s exact test as appropriate. Values are presented as mean (standard deviation) or proportion (percent). Abx appropriate antibiotic therapy, PRISM pediatric risk of mortality score, PELOD pediatric logistic organ dysfunction score, PICU pediatric ICU