Table 2.

Univariate analysis for predictors of prolonged ventilation and PICU length of stay, and for drop in PELOD score between days 1 to 3 of sepsis

Variable	Ventilated 1–7 d	Ventilated >7 d	P value	PICU 0–7 d	PICU >7 d	P value	Δ PELOD ≤ median	Δ PELOD > median	P value
Number	45	19		33	46		40	35
Age, months	82 (62)	62 (66)	0.17	90 (64)	67 (63)	0.12	60 (65)	94 (59)	0.022
PRISM	10.4 (6.1)	14.5 (8.6)	0.02	10.3 (5.5)	13.0 (8.3)	0.11	11.5 (6.6)	12.7 (7.5)	0.45
PELOD	14.4 (8)	20.7 (11)	0.007	14.4 (8.6)	17.8 (10.4)	0.13	-	-
Severe underlying disease	18/45 (40 %)	19/29 (66 %)	0.056	11/33 (33 %)	28/46 (61 %)	0.022	22/40 (55 %)	14/35 (40 %)	0.25
Delta PELOD	6.9 (8.4)	2.7 (14.0)	0.12	8.1 (8.4)	3.4 (11.9)	0.06	-	-
Time to Abx	243 (306)	235 (359)	0.92	223 (296)	243 (336)	0.79	234 (329)	239 (325)	0.95
Abx in first hour	10/45 (22 %)	9/29 (31 %)	0.43	5/33 (15 %)	15/46 (33 %)	0.12	13/40 (33 %)	7/35 (20 %)	0.30
Time to inotropes	546 (395)	428 (342)	0.32	654 (368)	428 (359)	0.056	533 (421)	493 (344)	0.74
Inotropes within 3 h	6/24 (25 %)	5/18 (28 %)	0.66	2/15 (13 %)	9/29 (31 %)	0.27	6/20 (30 %)	4/22 (18 %)	0.34
Time to 20 ml/kg volume	225 (247)	132 (179)	0.22	212 (220)	185 (252)	0.75	233 (306)	152 (167)	0.32
Volume in 2 h	20.2 (17.6)	36.7 (34.9)	0.05	23 (18.9)	29 (30.2)	0.48	23 (23)	33 (30)	0.27
Volume ≤20 ml/kg in 2 h	16/24 (67 %)	9/18 (50 %)	0.35	10/15 (67 %)	16/29 (55 %)	0.53	14/20 (70 %)	10/22 (45 %)	0.098
Volume to inotropes	35.2 (32.1)	46.7 (34.4)	0.27	41 (35)	39 (32)	0.88	37 (28)	46 (36)	0.35
Ventilator days	-	-		-	-		10.3 (11.2)	5.8 (5.1)	0.036
PICU days	-	-		-	-		15.8 (17.8)	9.7 (8.1)	0.071

Comparisons were performed using the t test for independent samples, and Fisher’s exact test as appropriate. Values are given as mean (standard deviation) or proportion (percent); times are given in minutes. PICU pediatric ICU, PELOD pediatric logistic organ dysfunction score, Abx antibiotic therapy