Figure 1.

Task-driven imaging framework. Specification of imaging task includes the location, contrast, and spatial frequencies of interest. In this work, a patient-specific model is given by a previous CT scan. Imaging parameters Ω_A and Ω_R define the acquisition and reconstruction technique, respectively. Theoretical predictors of spatial resolution and noise are derived from cascaded systems analysis of the imaging chain. The parameters that maximize d’ are identified prospectively (i.e., before image acquisition) via multivariate optimization.