Figure 3.

Neuregulin 1 (NRG1) reduces extracellular glutamate and glycine in the prefrontal cortex (PFC) in vivo. Mice (n = 8–10/treatment) received a local infusion of NRG1 (10nM), PCP (10 µM), or NRG1 + PCP for 10min in the PFC by retrodialysis. Extracellular GABA (A & B), glutamate (C & D), and glycine (E & F) levels are expressed as a percentage of the respective mean baseline value ± standard error of the mean for each time point (A, C, E) or baseline equivalent for area under the curve analysis (B, D, F). Dotted lines indicate baseline levels before each treatment. *p < 0.05 NRG1 + PCP vs baseline; ^# p < 0.05 PCP vs baseline; ⁺ p < 0.05, ⁺⁺ p < 0.01 NRG1 vs baseline.