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. 2015 Feb 19;18(7):pyu114. doi: 10.1093/ijnp/pyu114

Figure 4.

Figure 4.

Neuregulin 1 (NRG1) prevents PCP-induced increase in GABA levels and reduces extracellular glutamate in the presence of PCP in the dorsal hippocampus CA1 (dCA1) in vivo. Mice (n = 8–10/treatment) received a local infusion of NRG1 (10nM), PCP (10 µM), or NRG1 + PCP for 10min in the dCA1 by retrodialysis. Extracellular GABA (A & B), glutamate (C & D), and glycine (E & F) levels are expressed as a percentage of the respective mean baseline value ± standard error of the mean for each time point (A, C, E) or baseline equivalent for area under the curve analysis (B, D, F). Dotted lines indicate baseline levels before each treatment. T*p = 0.07, *p < 0.05, **p < 0.001 NRG1 + PCP vs baseline; T# p = 0.06, # p < 0.05, ## p < 0.01 PCP vs baseline; T+ p = 0.07, + p < 0.05, ++ p < 0.001 NRG1 vs baseline.