Table 2.
Predictive Ability of Serotonin Transporter (SERT) Non-displaceable Binding Potential (BPND) Ratios to Distinguish Responders from Nonresponders or “Other” Group.
| Responders vs nonresponders (total n = 21) | Responders vs other group (total n = 39) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cutoff point | Sensitivity (%) | Specificity (%) | Predictive power (%) | AUC (%) | p value | Cutoff point | Sensitivity (%) | Specificity (%) | Predictive power (%) | AUC (%) | p value | |
| TH/MB ratio | 0.78 | 100 | 56 | 78 | 73 | 0.076 | 0.86 | 92 | 59 | 75 | 78 | 0.006** |
| ST/MB ratio | 0.76 | 83 | 67 | 75 | 76 | 0.047* | 0.77 | 83 | 70 | 77 | 75 | 0.014* |
| PFC/MB ratio | 0.31 | 92 | 56 | 74 | 71 | 0.102 | 0.31 | 92 | 59 | 75 | 73 | 0.026* |
The cutoff point of SERT BP ratios as the predictor by plotting the proportion of true positive result (sensitivity) versus the proportion of false-positive results (1-specificity). The area under the curve (AUC) indicates area under the receiver operator characteristic (ROC) curves (*p < 0.05, **p < 0.01). Other group indicates combined nonresponders and dropout subjects. MB, midbrain; PFC, prefrontal cortex; ST, striatum; TH, thalamus.