Table 2.
Genotypes and the Association with BMI Gain for the Total Sample (n = 212)
| Gene | SNP | BMI gain (kg/m2) (n) | p-valuea | Gene | SNP | BMI gain (kg/m2) (n) | p-valuea |
|---|---|---|---|---|---|---|---|
| NPY | rs16147 | AA 0.79±1.21 (29) | 0.227 | BDNF | rs1519480 | CC 0.87±1.3 (19) | 0.906 |
| AG 0.57±0.89 (92) | CT 0.69±1.22 (94) | ||||||
| GG 0.93±1.43 (91) | TT 0.79±1.18 (99) | ||||||
| rs3037354 | TG/TG 0.89±1.23 (91) | 0.105 | FTO | rs9939609 | AA 1.2±1.3 (4) | 0.780 | |
| TG/- 0.55±0.91 (99) | AT 0.83±1.17 (40) | ||||||
| -/- 1.05±1.86 (22) | TT 0.72±1.21 (168) | ||||||
| MC4R | rs17782313 | CC 0.41±0.6 (9) | 0.429 | ANKK1 | rs1800497 | CC 1.01±1.37 (73) | 0.017b |
| CT 0.92±1.47 (66) | CT 0.76±1.22 (91) | ||||||
| TT 0.69±1.07 (137) | TT 0.35±0.69 (48) | ||||||
| rs489693 | AA 0.87±0.81 (9) | 0.617 | DRD2 | rs1079598 | CC 0.55±0.83 (42) | 0.583 | |
| AC 0.62±0.99 (78) | CT 0.76±1.27 (113) | ||||||
| CC 0.83±1.34 (125) | TT 0.89±1.29 (57) | ||||||
| rs8087522 | AA 0.45±0.83 (4) | 0.868 | PRKAA2 | rs10789038 | AA 0.69±1.27 (150) | 0.020b | |
| AG 0.74±1.0 (53) | AG 0.87±0.99 (54) | ||||||
| GG 0.76±1.27 (155) | GG 1.23±1.08 (8) | ||||||
| LEP | rs10954173 | AA 0.61±0.91 (12) | 0.110 | PRKAB2 | rs3766522 | AA 0.67±0.85 (5) | 0.794 |
| AG 0.57±1.25 (73) | AT 0.66±0.89 (56) | ||||||
| GG 0.87±1.15 (127) | TT 0.79±1.31 (151) | ||||||
| rs3828942 | AA 0.8±1.16 (103) | 0.562 | PRAKG3 | rs692243 | CC 0.76±1.1 (52) | 0.334 | |
| AG 0.75±1.3 (91) | CG 0.81±1.26 (117) | ||||||
| GG 0.5±0.88 (18) | GG 0.59±1.16 (43) | ||||||
| LEPR | rs1137101 | AA 1.71±1.49 (4) | < 0.001c | MTHFR | rs1801133 | CC 0.85±1.33 (119) | 0.357 |
| AG 1.19±1.18 (46) | CT 0.62±1.04 (76) | ||||||
| GG 0.6±1.17 (162) | TT 0.65±0.9 (17) | ||||||
| rs1327120 | AA 0.74±1.21 (176) | 0.574 | HTR 2C | rs3813929 | C/CC 0.74±1.20 (181) | 0.508 (Total) | |
| AG 0.73±1.13 (32) | CT 0.68±1.04 (12) | ||||||
| GG 1.37±1.69 (4) | T/TT 0.94±1.34 (19) | ||||||
| BDNF | rs6265 | AA 0.78±1.53 (43) | 0.850 | rs3813929 | CC 0.62±1.01 (72) | 0.774 (Female)d | |
| AG 0.78±1.09 (111) | CT/TT 0.57±0.95 (14) | ||||||
| GG 0.68±1.13 (58) | rs3813929 | C 0.82±1.32 (109) T 1.07±1.42 (17) |
0.204 (Male)d |
a Analyses of covariance with gender, age, and baseline BMI (kg/m2) as covariates.
b p < 0.05.
c The association of rs1137101 with BMI change remained significant after the Bonferroni correction, which was set at p < 0.0026 (0.05/19 SNPs).
d Sex-specific analyses for HTR 2C rs3813929 (on the X chromosome); p-values calculated using Mann–Whitney U.
AMPK, AMP-activated protein kinase; ANKK1, ankyrin repeat kinase domain containing 1; BDNF, brain-derived neurotrophic factor; DRD2, dopamine 2 receptor gene; FTO, fat mass and obesity associated; HTR 2C, serotonergic 2C-receptor; LEP, leptin; LEPR, leptin receptor; MC4R, melanocortin4 receptor; MTHFR, methylenetetrahydrofolate reductase; NPY, neuropeptide Y; PRKAA2, α2 catalytic subunit of AMPK; PRKAB2, β2 non-catalytic subunit of AMPK; PRAKG3, γ3 non-catalytic subunit of AMPK; SNP, single nucleotide polymorphism.