. 2015 Apr 2;18(7):pyv021. doi: 10.1093/ijnp/pyv021

Table 3.

The Association Between LEPR rs1137101, ANKK1 rs1800497, and PRKAA2 rs10789038 Genotypes with BMI Gain Within 6 Months After Initiation of VPA Treatment (n = 212)

	1 month	2 months	3 months	4 months	5 months	6 months
LEPR rs1137101
AA	0.08±0.09	0.40±0.30	0.89±0.66	1.23±1.01	1.45±1.23	1.71±1.49
AG	0.08±0.14	0.28±0.34	0.63±0.64	0.86±0.87	1.05±1.06	1.19±1.18
GG	0.05±0.18	0.22±0.42	0.34±0.68	0.45±0.87	0.55±1.06	0.6±1.17
p-value^a	0.448	0.184	0.004^b	0.002^c	0.002^c	< 0.001^c
ANKK1 rs1800497
CC	0.07±0.17	0.28±0.42	0.57±0.78	0.76±1.03	0.90±1.22	1.01±1.37
CT	0.07±0.22	0.24±0.49	0.42±0.70	0.55±0.91	0.68±1.12	0.76±1.22
TT	0.02±0.04	0.10±0.18	0.17±0.34	0.25±0.47	0.32±0.60	0.35±0.69
p-value^a	0.199	0.055	0.004^b	0.007^b	0.011^b	0.017^b
PRKAA2 rs10789038
AA	0.05±0.13	0.19±0.36	0.37±0.66	0.50±0.91	0.61±1.13	0.69±1.27
AG	0.09±0.28	0.31±0.56	0.52±0.73	0.67±0.85	0.79±0.95	0.87±0.99
GG	0.06±0.56	0.26±0.25	0.65±0.62	0.93±0.92	1.09±1.06	1.23±1.08
p-value^a	0.194	0.049^b	0.080	0.085	0.089	0.020^b

^a p-values calculated using analyses of covariance with gender, age, and baseline BMI (kg/m²) as covariates.

^b p < 0.05.

^c The difference remained significant after the Bonferroni correction, which was set at p < 0.0026 (0.05/19 SNPs).

ANKK1, ankyrin repeat kinase domain containing 1; LEPR, leptin receptor; PRKAA2, α2 catalytic subunit of AMPK; SNP, single nucleotide polymorphism ; VPA, valproic acid.