Figure 2.

Effects of acutely administered cocaine on locomotor activity in adolescent (A-B) and adult (C-D) rats with free access to either standard or high fat chow or restricted access to high fat chow for either 1 (A,C) or 4 (B,D) weeks. Each condition represents the mean ±SEM of 6 rats (i.e., data from different groups of rats are presented in different panels with symbols designating feed condition). Abscissae: dose in mg/kg of body weight; data points above V indicate the effects obtained with vehicle. Ordinates: mean locomotor activity counts/5min (±SEM). *P<.05 compared with rats that ate standard chow throughout the study at the corresponding dose of cocaine and analyzed by a 2-way (dose and feeding condition), repeated-measures ANOVA with posthoc Bonferroni’s test.