Human toxicity
	Software	EPI Suite	VEGA	TEST	ToxPredict	Toxtree	OCHEM	DEMETRA	CORALSEA	Chembench	TOPKAT
In vitro skin irritation/corrosion						1					3
In vitro eye irritation/corrosion						1					3
Skin sensitization			1			1				2	2
In vitro mutagenicity			1	4	1	1	1			2	1
In vitro cytogenicity mammalian cells					1
In vivo mutagenicity mammalian cells						1
Inhalation acute toxicity											1
Acute oral toxicity				4					1	1	1
Dermal acute toxicity		1									1
Short-term repeated dose toxicity (28 d)					1						1
Sub-chronic repeated dose study (90 d)											1
Developmental toxicity			1	6
Carcinogenicity			1		6	1					13

Numbers indicate the number of models in each software.

QSAR, quantitative structure-activity relationships; K-REACH, Act on the Registration, Evaluation, Authorization, and Restriction of Chemical Substances.