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. 2015 Jun 19;107(4):546–555. doi: 10.1093/cvr/cvv176

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© The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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cAMP signalling can inhibit human VSMC migration via multiple mediators. VSMC were added to the chemotaxis chamber in the presence of PDGF (10 ng/mL). (A) PDGF-induced migration was inhibited in the presence of Sp-cAMPS (20 µmol/L), 6-Phe-cAMP (5 µmol/L), or 8-Me-cAMP (2 µmol/L), n = 5. (B) The simultaneous addition of 6-Phe-cAMP (5 µmol/L) and 8-Me-cAMP (2 µmol/L) in the presence of PDGF had no further effect on VSMC migration in comparison with 6-Phe-cAMP or 8-Me-cAMP alone, n = 5, **P < 0.01, ***P < 0.001. Data are expressed as mean ± SEM Percentage of migration in comparison to the control.