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. 2015 Jun 19;107(4):568–578. doi: 10.1093/cvr/cvv179

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© The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Signal transduction by CBD in human endothelial cells. Levels of phosphorylated ERK/MAP kinase 1/2 (A) and Akt (B) measured in human aortic endothelial cell lysates after 10 min treatment with CBD in the presence of the CB₁ antagonist AM251 (100 nM) or the TRPV1 antagonist capzasepine (1 μM). (C) Correlation of levels of phosphorylated ERK1/2 and Akt with levels of phosphorylated eNOS in human aortic endothelial cell lysates after 10 min treatment with CBD. MFI, median fluorescent intensity. (D) The effects of the CB₁ receptor antagonist AM251 on CBD-stimulated eNOS phosphorylation. Data are presented as mean ± SEM (n = 6) and were analysed by ANOVA with Sidak's multiple comparison test of selected pairs. **P < 0.01, ***P < 0.001.