. 2015 Aug 11;8:2089–2096. doi: 10.2147/OTT.S86908

Table 1.

Summary of the publications included in this meta-analysis

Study	Country	Specimen	Method	Cancer type	Case	Control	miRNA profiling	Sensitivity (%)	Specificity (%)	QUADAS score
Mengual et al²¹	Spain	Voided urine	qRT-PCR	UCC	181	136	miR-187, miR-140-5p, miR-18a, miR-25, miR-204, and miR-142-3p	84.8	86.5	8
Miah et al²⁰	UK	Urine sediment	RT-PCR	UCC	68	53	miR-15a	51.7	72	7
							miR-15b	67.8	81.3
							miR-24-1	60	58.5
							miR-27b	60.3	81.1
							miR-100	60.4	78.7
							miR-135b	71.2	74.4
							miR-203	66.1	66
							miR-212	54.2	64
							miR-328	55.4	86.8
							miR-1224	75.9	82.4
							Combination of miRs 135b/15b/1224-3p	94.5	51
Yamada et al¹⁸	Japan	Urine sediment	RT-PCR	UC	100	74	miR-96	71	89.2	5
							miR-183	74	77.3
Hanke et al⁸	Germany	Voided urine	RT-PCR	BCa	18	18	miR-126:miR-152	72	82	7
Snowdon et al¹⁰	USA	Voided urine	qRT-PCR	UC	8	5	miR-125b,miR-126	80	100	9
Yun et al¹⁷	Korea	Urine supernatant	RT- PCR	TCC	207	144	miR-145	77.8	61.1	7
Zhang et al¹⁶	People’s Republic of China	Urine supernatant	qRT-PCR	UCB	50	21	miR-99a and miR-125b	90	90	9
							miR-99a	78	85.7
							miR-125b	84.8	76.2
Wang et al⁹	People’s Republic of China	Urine sediment	qRT-PCR	BCa	51	24	miR-200a	100	52.6	9
Tölle et al¹⁹	Germany	Voided urine	qRT-PCR	BCa	36	19	miR-1255b-5p	85	68.4	9
							miR-618	70	68.4

Note: All miRNAs are determined at a statically significant level (P<0.05).

Abbreviations: miRNA, microRNA; qRT-PCR, quantitative reverse transcription polymerase chain reaction; RT-PCR, real-time polymerase chain reaction; UCC, urothelial cell carcinoma; BCa, bladder cancer; UC, urothelial carcinoma; UCB, urothelial carcinoma of the bladder; TCC, transitional cell carcinoma; QUADAS, Quality Assessment of Diagnostic Accuracy Studies.