Table 2.

Summary estimates of diagnostic criteria and their 95% CI

Subgroups	Sensitivity (95% CI)	Specificity (95% CI)	Positive LR (95% CI)	Negative LR (95% CI)	DOR (95% CI)	AUC (95% CI)
miRNA profiling
Single miRNA	0.72 (0.65–0.78)	0.74 (0.69–0.79)	2.79 (2.31–3.37)	0.38 (0.31–0.47)	7.30 (5.15–10.36)	0.79 (0.76–0.83)
Multiple miRNAs	0.86 (0.78–0.91)	0.82 (0.65–0.91)	4.65 (2.39–9.06)	0.17 (0.12–0.25)	27.32 (14.84–50.28)	0.91 (0.88–0.93)
Specimen
Voided urine	0.77 (0.66–0.84)	0.76 (0.63–0.85)	3.12 (1.98–4.91)	0.31 (0.21–0.47)	9.99 (4.71–21.22)	0.81 (0.78–0.85)
Urine supernatant	0.81 (0.75–0.86)	0.74 (0.60–0.85)	3.13 (1.90–5.15)	0.26 (0.18–0.37)	12.20 (5.46–27.25)	0.84 (0.81–0.87)
Urine sediment	0.73 (0.63–0.81)	0.75 (0.69–0.81)	2.96 (2.34–3.73)	0.36 (0.26–0.49)	8.20 (5.17–13.03)	0.81 (0.77–0.84)
Overall	0.75 (0.68–0.80)	0.75 (0.70–0.80)	3.03 (2.50–3.67)	0.33 (0.27–0.42)	9.07 (6.35–12.95)	0.81 (0.78–0.85)

Abbreviations: CI, confidence interval; miRNA, microRNA; DOR, diagnostic odds ratio; AUC, area under the curve; LR, likelihood ratio.