TABLE 1.
Summary of family cancer history in patients with early onset uveal melanoma included in the study
| Patient ID | Reference of previous report | Age* | Gender | Other malignancy in patient | Malignancy in relatives | Tumor location | Tumor size (base × height, mm) | Treatment | AJCC T Category |
|---|---|---|---|---|---|---|---|---|---|
| FUM1474 | – | 29 years | F | None | CM and Prostate(F), Colon (PGM), Breast (M), CM (MU), Prostate (MGF) | Choroid | NA | FNAB, brachytherapy | N/A |
| FUM039 | 4 | 28 years | M | None | CM (B) | Choroid | 6.5 × ? | Brachytherapy | N/A |
| FUM101 | 12 | 28 years | F | None | None | Choroid | 14 × 12 | Enucleation | T3 |
| FUM012 | 4 | 27 years | M | None | Breast (MU), CASU (MU), Lung (MGM, Eye NOS (MC) | Ciliary body | 10 × 9 | Enucleation | T2 |
| FUM078 | 12 | 27 years | M | None | CM (PGF), Brain (PC) | Choroid | 18 × 4 | Enucleation | T4 |
| FUM014 | 4 | 27 years | F | None | Cervix (S), Lymphoma (MGM) | Choroid | 3 × 4 | No treatment | T1 |
| FUM063 | 12 | 25, 30 years (bilateral) | F | Breast | Acoustic neuroma and Astrocytoma (S) Throat (F), Throat (PU), Head & Neck (PA), Bladder (MA), Head & neck (MU) | NA | NA | NA | N/A |
| FUM069 | 12 | 23 years | F | None | Breast (PGGM), Prostate (PGGF) | Ciliary body | 3.8 × 3.3 | Iridocyclectomy | T1 |
| FUM013 | 4 | 19 years | F | None | Lymphoma & Breast (PA), Breast (PA), Colon (MU), Sinus (MGF) | Choroid | 12 × 3 | Brachytherapy | T1 |
| FUM152 | – | 18 years | F | None | UM (F), Cancer NOS (PGF) | Choroid | 6.5 × 3.5 | Brachytherapy | T1 |
| CEI6605 | – | 17 years | F | None | CM (MGM), Prostate (MGGM), Prostate (PGGF) | Iris | 9 × ? | FNAB, brachytherapy | N/A |
| CEI6627 | – | 17 years | M | None | Skin NOS (PA), Pancreas (PC), Bone and Prostate (PGF) | Iris | NA | Iridectomy | N/A |
| FUM066 | 12 | 15 years | F | None | Testicular (F) | Choroid | 7 × 1.7 | Brachytherapy | T1 |
| CEI6601 | – | 3 months | F | None | None | Ciliochoroidal with extrascleral involvement | 20 × 4 | Enucleation | T4 |
Family history symbols: F, father; M, mother; P, paternal side of the family; M, maternal side of the family; S, sister; B, brother; GM, grandmother; GF, grandfather; A, paternal aunt; U, uncle; C, cousin; GGF, great grandfather; GGM, great grandmother; CaSU, cancer site unknown; CM, cutaneous melanoma; N/A, not available; NOS, not otherwise specified; WT, wild type
*
age at diagnosis