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Schematic figures showing p-MAP4 translocation-mediated mitochondrial cardiomyocyte apoptosis under hypoxia stress. MAP4 is primarily bound to cytosolic microtubule and plays an important role in microtubule dynamics. When intrinsic apoptosis pathway is activated by hypoxia, MAP4 dissociates from the tubulin once being phosphorylated, with microtubule instability as a consequence. Phosphor-MAP4 (p-MAP4) is translocated to mitochondria and leads to mPTP opening and apoptosis
