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. 2014 Sep 4;5(9):e1405. doi: 10.1038/cddis.2014.372

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Rbf1-induced apoptosis involves dE2F2 and dDP. (a) Wing phenotypes were grouped in four categories (wild type, weak, intermediate and strong) according to the number of notches observed on the wing margin (asterisks). (b–d) Distribution of notch wing phenotypes in vg-Gal4>UAS-rbf1, vg-Gal4>UAS-rbf1; de2f2^76Q1 and vg-Gal4>UAS-rbf1, UAS-de2f2 (b), in vg-Gal4>UAS-rbf1 and vg-Gal4>UAS-rbf1; dDp^a1 (c), and in vg-Gal4>UAS-rbf1 and vg-Gal4>UAS-rbf1; de2f1ⁱ² (d). Statistical analysis was performed using Wilcoxon tests. Each experiment was independently performed three times; as the results were similar, only one experiment is presented here. (e–j) Apoptotic cells were visualized by TUNEL staining (white dots) of wing imaginal discs of the genotype indicated at the top of the image. All the pictures are at the same scale, scale bar: 100 μm. (k–m) Quantification of TUNEL-positive cells in the wing pouch. Asterisks indicate a statistically significant difference between two genotypes (Student's t-test, P<0.05)