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. 2014 Sep 4;5(9):e1405. doi: 10.1038/cddis.2014.372

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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rbf1 overexpression induces downregulation of buffy and diap1 mRNA. (a–c) Quantification of buffy (a, b) and diap1 (c) mRNA by RT-qPCR in wing imaginal discs. Data are normalized against rp49 and correspond to the mean of three independent experiments. Error bars are the S.E.M. Asterisks indicate statistical significant difference between two genotypes (Student's t-test, P<0,05). (d, e) Distribution of notches in wings of vg-Gal4>UAS-rbf1, vg-Gal4>UAS-rbf1; buffy^H37 and vg-Gal4>UAS-rbf1; UAS-buffy flies (d), vg-Gal4>UAS-rbf1, vg-Gal4>UAS-rbf1; UAS-RNAi-diap1 and vg-Gal4>UAS-rbf1; UAS-diap1 flies (e). Wing phenotypes were grouped in four categories according to the number of notches (wild type, weak, intermediate, strong). Statistical analysis was performed using Wilcoxon tests. Each experiment was independently performed three times; as the results were similar, only one experiment is presented here. (f, g) Quantification of TUNEL-positive cells in the wing pouch. Asterisks indicate a statistically significant difference between two genotypes (Student's t-test, P<0.05)