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. 2014 Sep 4;5(9):e1405. doi: 10.1038/cddis.2014.372

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Mip proteins and Myb are differentially involved in Rbf1-induced apoptosis. (a–c) Distribution of notch wing phenotypes in vg-Gal4>UAS-rbf1,UAS-cherry and vg-Gal4>UAS-rbf1,UAS-RNAi-mip120 (a), in vg-Gal4>UAS-rbf1,UAS-cherry and vg-Gal4>UAS-rbf1; UAS-RNAi-mip130 (b) and in vg-Gal4>UAS-rbf1 and vg-Gal4>UAS-rbf1; UAS-myb (c). Wing phenotypes were grouped in four categories according to the number of notches (wild type, weak, intermediate, strong). Statistical analysis was performed using Wilcoxon tests. Each experiment was independently performed three times; as the results were similar, only one experiment is presented here. (d–f) Quantification of TUNEL-positive cells in the wing pouch of genotypes studied in (a–c). Asterisks indicate a statistically significant difference between two genotypes (Student's t-test, P<0.05). (g–j) Quantification of buffy (g, h) and how (i, j) mRNA in wing imaginal discs by RT-qPCR. Data are normalized against rp49 and correspond to the mean of three independent experiments. Error bars are the S.E.M. Asterisks indicate statistically significant difference between two genotypes (Student's t-test, P<0.05)