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. 2014 Sep 25;5(9):e1425. doi: 10.1038/cddis.2014.384

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Copyright © 2014 Macmillan Publishers Limited

is an open-access journal published by . This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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Treatment with SKI alone or in combination with TMZ induces ER dilation. Cells were treated with 10 μM SKI, 500 μM TMZ and the combination of both and analyzed 48 h later by light (a) and electron (b) microscopy. (a) Cytoplasmic vacuolization is observed in NCH82 cells but not in astrocytes. Arrows point to exemplary cells showing cytoplasmic vacuolization. Magnification: × 20. (b) ER enlargement in NCH82 cells. Arrows point exemplarily to the rough ER, arrowhead to the nuclear membrane. Control, SKI, and TMZ conditions: pictures on the right represent magnifications of the framed regions of interest. N, nucleus