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. 2014 Sep 25;5(9):e1425. doi: 10.1038/cddis.2014.384

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Copyright © 2014 Macmillan Publishers Limited

is an open-access journal published by . This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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GPx1 activity confers resistance to human astrocytes towards induction of vacuolization and cell death induced by (SKI+TMZ) and its expression correlates with cell's sensitivity to (SKI+TMZ) treatment. (a) Morphology of astrocytes after 48 h of treatment with (SKI+TMZ) in the presence or absence of 2.5 mM MSA. The arrow points to an exemplary cell showing vacuolization. Magnification: × 20. (b) Cell death of astrocytes after 72 h of treatment with (SKI+TMZ) in the presence or absence of 2.5 mM MSA was determined by TO-PRO staining. Results shown are the mean±S.E.M. of three independent experiments. ***P<0.001 compared with control±MSA and to (SKI+TMZ). (c) GPx1 expression in human glioblastoma cell lines and human astrocytes. Levels of 14.3.3 expression were used as a protein loading control. One experiment representative of two independent experiments is shown