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. Author manuscript; available in PMC: 2015 Aug 18.
Published in final edited form as: J Neurochem. 2013 Jan 7;125(3):430–445. doi: 10.1111/jnc.12130

Figure 6. TCDD reduces cell proliferation in adult hippocampus without inducing cell death.

Figure 6

(A)Paradigm used to investigate neural cell proliferation in the dentate gyrus 8h and 24h following TCDD exposure. (B) Quantification of BrdU+ cells in the SGZ demonstrated a reduction in S-phase entry 8h after TCDD exposure compared to vehicle-treated animals, which became more pronounced at 24h. (C) Quantification of Ki67-positive cells revealed a significant reduction in newborn cells in all phases of the cell cycle following 24h exposure to TCDD, but not at 8h. (D) Quantification of CC3-single and CC3- and BrdU-double positive cells relative to total number of BrdU-positive cells in the SGZ demonstrated that TCDD does not induce apoptosis at either timepoint. All results are expressed as means ± S.E.M. (N=10 mice/group); Student's t-test (* p<0.05, ** p <0.01).