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. Author manuscript; available in PMC: 2015 Aug 18.
Published in final edited form as: Virology. 2009 Jul 9;391(2):265–273. doi: 10.1016/j.virol.2009.05.032

Fig. 1.

Fig. 1

Expression of pulmonary receptor for advanced glycation end products (RAGE) during influenza A virus (IAV) pneumonia. Shown are representative RAGE stainings (original magnification, × 10) of lung tissue (A–D). Normal, uninfected wild-type (wt) mouse (A) displaying extensive RAGE expression in the interalveolar septae with an endothelial pattern. Arrow indicates bronchial epithelium being negative for RAGE staining. Absence of RAGE positivity in the lung of a RAGE−/− mouse (B). Lungs form a wt mouse 8 days after the inoculation of IAV (C and D). Arrow in C indicates bronchial epithelium being positive for RAGE staining (compared with A) and arrows in D indicate inflammatory cells being positive for RAGE staining. Soluble (s)RAGE levels in bronchoalveolar lavage fluid (BALF) from normal, uninfected wt mice (open bar) and from mice 8 days after IAV inoculation (E) (filled bar, n=5–6 mice per group). ***P<0.005, vs. healthy, uninfected mice (Mann–Whitney U test).