Fig. 4.

Lung histopathology. Shown are representative hematoxylin–eosin stainings (original magnification, × 10) of lung tissue of wt (A) and receptor for advanced glycation end product deficient (RAGE^−/−; B) mice obtained 8 days after inoculation with influenza A virus (IAV). Total histology scores of the lungs were determined in wt and RAGE^−/− mice 8 days after influenza virus inoculation (C) as described in the Materials and methods section. Data are means ± SEs (n=8–9 mice/genotype). *P<0.05, vs. wt mice (Mann–Whitney U test).