Associations of diabetes, mediators of brain pathology markers, and cognitive function. (A) Memory function; (B) processing speed; (C) executive function. β-Coefficient (standard error) was derived from the mediation models controlling for age, sex, education, current smoking, and midlife hypertension. CMB=cerebral microbleeds; GM=gray matter; WM=white matter; WML=WM lesion. *p < 0.05, †p < 0.01. [Color figure can be viewed in the online issue, which is available at www.annalsofneurology.org.]