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Schematic representation of protocol used to derive topotecan/pazopanib resistant ovarian cancer variants 7SD and 7AS using the SKOV-3-13 cell line as a starting point. Mice were treated with metronomic topotecan plus pazopanib for 13 weeks. Six weeks after cessation of treatment, tumor growth began to recur. At this time, treatment was re-initiated but mice failed to respond to the therapy
