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As previously reported [13], a combination of metronomic topotecan and pazopanib inhibited progression of metastatic disease in mice implanted with the SKOV-3-13 cell line. However, mice implanted with variants −7SD or −7AS and treated with the same combination chemotherapy, showed a shorter median survival (n = 5 mice for all groups, Kaplan–Meier P < 0.05 taken as statistical indication of difference between parental and 7AS and 7SD)
