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. Author manuscript; available in PMC: 2015 Aug 18.
Published in final edited form as: Angiogenesis. 2014 Feb 26;17(3):661–673. doi: 10.1007/s10456-014-9422-9

Fig. 3.

Fig. 3

Effect of topotecan (a) and Pazopanib (b), on in vitro cell proliferation by MTS assay. The anti-proliferative effects of the drugs were studied using daily exposures (144 h) on SKOV-3-13 (c), 7SD (d) and 7AS (e) cell lines by trypan blue dye exclusion. Both7AS and 7SD showed significantly higher cell viability in the presence of topotecan than was the case for their parental cell line SKOV-3-13. Symbols and bars indicate mean values ± SD, respectively. *P < 0.05 and **P < .01 versus vehicle-treated controls. IC50 indicates the concentration of drug that reduced cell proliferation by 50 %