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. Author manuscript; available in PMC: 2015 Aug 18.
Published in final edited form as: Angiogenesis. 2014 Feb 26;17(3):661–673. doi: 10.1007/s10456-014-9422-9

Fig. 4.

Fig. 4

a SKOV-3-13 and 7SD cells were cultured in vitro for 144 h in the presence of a combination of topotecan/pazopanib and under either normoxic or hypoxic (1 % O2) conditions. Cell viability was examined by means of MTS assay. Values for cell viability in hypoxic conditions are expressed relative to their respective values in normoxic conditions. The parental cell line SKOV-3-13 showed poorer cell viability under hypoxia and topotecan/pazopanib treatment than the resistant variant 7SD. b Accumulation of topotecan in SKOV-3-13, 7AS and 7SD cell lines after exposure to 1 µM topotecan. Columns and bars indicate mean values ± SD, respectively. *P < .001 versus SKOV cell line