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Subsequent passages of variant 7SD and parental SKOV-3-13 were re-implanted as described above in SCID mice and treated with the combination of metronomic topotecan and pazopanib. As before, mice implanted with SKOV-3-13 cell line continued to show significant response to the combination resulting in complete survival (even 350 days post-tumor cell implantation) and those implanted with resistant variant 7SD showed poorer response (P < 0.05, n = 5 mice for all groups)
