Table 1. Genotype and allele frequencies of the selected SNPs in CDH1 and CTNNB1 and their associations with risk of breast cancer.
| SNPs | Genotype | Cases (%) | Controls (%) | P a | P b | P trend | OR (95% CI) | P | aOR (95% CI) c | P c |
|---|---|---|---|---|---|---|---|---|---|---|
| rs7200690 CDH1 | CC | 744 (64.14) | 852 (63.77) | 0.0240 | 0.4103 | Reference | Reference | |||
| CT | 335 (28.88) | 422 (31.59) | 0.91 (0.76–1.08) | 0.2826 | 0.91 (0.76–1.08) | 0.2736 | ||||
| TT | 81 (6.98) | 62 (4.64) | 1.50 (1.06–2.11) | 0.0221 | 1.50 (1.06–2.12) | 0.0208 | ||||
| T allele frequency | 497 (21.42) | 546 (20.43) | 0.3916 | |||||||
| CT/TT vs. CC (dominant model) | 0.98 (0.84–1.16) | 0.8496 | 0.98 (0.84–1.16) | 0.8425 | ||||||
| TT vs. CT/CC (recessive model) | 1.54 (1.10–2.17) | 0.0126 | 1.55 (1.10–2.18) | 0.0116 | ||||||
| rs12185157 CDH1 | AA | 337 (29.05) | 387 (28.97) | 0.6334 | 0.6277 | Reference | Reference | |||
| AG | 540 (46.55) | 643 (48.13) | 0.91 (0.75–1.11) | 0.3395 | 0.90 (0.74–1.10) | 0.3125 | ||||
| GG | 283 (24.40) | 306 (22.90) | 0.94 (0.76–1.17) | 0.5873 | 0.94 (0.75–1.16) | 0.5511 | ||||
| G allele frequency | 1106 (47.67) | 1255 (46.97) | 0.6193 | |||||||
| AG/GG vs. AA (dominant model) | 0.92 (0.77–1.11) | 0.3806 | 0.92 (0.76–1.10) | 0.3489 | ||||||
| GG vs. AG/AA (recessive model) | 1.004 (0.84–1.19) | 0.9629 | 0.996 (0.84–1.19) | 0.9659 | ||||||
| rs7198799 CDH1 | CC | 855 (73.71) | 981 (73.43) | 0.0296 | 0.4867 | Reference | Reference | |||
| CT | 258 (22.24) | 423 (24.25) | 0.91 (0.76–1.10) | 0.3451 | 0.91 (0.75–1.10) | 0.3237 | ||||
| TT | 47 (4.05) | 31 (2.32) | 1.74 (1.095–2.76) | 0.0190 | 1.75 (1.099–2.77) | 0.0183 | ||||
| T allele frequency | 352 (15.17) | 396 (14.45) | 0.4709 | |||||||
| CT/TT vs. CC (dominant model) | 0.99 (0.83–1.18) | 0.8749 | 0.98 (0.82–1.18) | 0.8477 | ||||||
| TT vs. CT/CC (recessive model) | 1.78 (1.12–2.82) | 0.0143 | 1.79 (1.13–2.83) | 0.0136 | ||||||
| rs17715799 CDH1 | AA | 781 (67.33) | 872 (65.27) | 0.0113 | 0.9953 | Reference | Reference | |||
| AT | 302 (26.03) | 403 (30.16) | 0.84 (0.70–1.10) | 0.0592 | 0.83 (0.70–1.10) | 0.0549 | ||||
| TT | 77 (6.64) | 61 (4.57) | 1.41 (0.99–2.00) | 0.0544 | 1.42 (0.998–2.001) | 0.0513 | ||||
| T allele frequency | 456 (19.66) | 525 (19.65) | 0.9951 | |||||||
| AT/TT vs. AA (dominant model) | 0.91 (0.77–1.08) | 0.2789 | 0.91 (0.77–1.08) | 0.2677 | ||||||
| TT vs. AT/AA (recessive model) | 1.49 (1.05–2.10) | 0.0245 | 1.50 (1.06–2.11) | 0.0227 | ||||||
| rs10431923 CDH1 | TT | 383 (38.02) | 438 (32.78) | 0.8221 | 0.8292 | Reference | Reference | |||
| GT | 544 (46.90) | 641 (47.98) | 0.94 (0.76–1.16) | 0.5392 | 0.93 (0.75–1.15) | 0.4851 | ||||
| GG | 233 (20.09) | 257 (19.24) | 0.96 (0.77–1.21) | 0.7516 | 0.96 (0.77–1.20) | 0.7075 | ||||
| G allele frequency | 1010 (43.53) | 1155 (43.23) | 0.8264 | |||||||
| GT/GG vs. TT (dominant model) | 0.95 (0.78–1.16) | 0.5937 | 0.94 (0.77–1.15) | 0.5395 | ||||||
| GG vs. GT/TT (recessive model) | 1.01 (0.86–1.20) | 0.9017 | 1.01 (0.85–1.20) | 0.9053 | ||||||
| rs7186053 CDH1 | GG | 602 (51.90) | 667 (49.93) | 0.0579 | 0.9724 | Reference | Reference | |||
| AG | 429 (36.98) | 548 (41.02) | 0.88 (0.73–1.03) | 0.0962 | 0.86 (0.73–1.02) | 0.0842 | ||||
| AA | 129 (11.12) | 121 (9.06) | 1.18 (0.90–1.55) | 0.2291 | 1.19 (0.91–1.56) | 0.2082 | ||||
| A allele frequency | 687 (29.61) | 790 (29.57) | 0.9715 | |||||||
| AG/AA vs. GG (dominant model) | 0.92 (0.79–1.08) | 0.3259 | 0.92 (0.79–1.10) | 0.3102 | ||||||
| AA vs. AG/GG (recessive model) | 1.26 (0.97–1.63) | 0.0872 | 1.27 (0.98–1.65) | 0.0742 | ||||||
| rs6499199 CDH1 | CC | 888 (76.55) | 1028 (76.95) | 0.2594 | 0.4872 | Reference | Reference | |||
| CT | 241 (20.78) | 285 (21.33) | 0.98 (0.81–1.19) | 0.8295 | 0.99 (0.82–1.20) | 0.9230 | ||||
| TT | 31 (2.67) | 23 (1.72) | 1.56 (0.90–2.70) | 0.1110 | 1.58 (0.91–2.73) | 0.1030 | ||||
| T allele frequency | 303 (13.06) | 331 (12.39) | 0.4766 | |||||||
| CT/TT vs. CC (dominant model) | 1.02 (0.85–1.23) | 0.8195 | 1.03 (0.86–1.25) | 0.7230 | ||||||
| TT vs. CT/CC (recessive model) | 1.57 (0.91–2.70) | 0.1063 | 1.58 (1.001–1.49) | 0.1004 | ||||||
| rs4783689 CDH1 | CC | 576 (49.66) | 646 (48.35) | 0.8095 | 0.5694 | Reference | Reference | |||
| CT | 465 (40.09) | 550 (41.17) | 0.95 (0.80–1.12) | 0.5323 | 0.95 (0.80–1.12) | 0.5069 | ||||
| TT | 119 (10.26) | 140 (10.48) | 0.95 (0.73–1.25) | 0.7274 | 0.95 (0.72–1.24) | 0.6913 | ||||
| T allele frequency | 703 (30.30) | 830 (31.06) | 0.5609 | |||||||
| CT/TT vs. CC (dominant model) | 0.95 (0.81–1.11) | 0.5164 | 0.95 (0.81–1.11) | 0.4846 | ||||||
| TT vs. CT/CC (recessive model) | 0.98 (0.75–1.26) | 0.8572 | 0.97 (0.75–1.26) | 0.8263 | ||||||
| rs13689 CDH1 | TT | 766 (66.03) | 875 (65.49) | 0.0047 | 0.4013 | Reference | Reference | |||
| CT | 330 (28.45) | 420 (31.44) | 0.90 (0.75–1.07) | 0.2226 | 0.90 (0.76–1.08) | 0.2586 | ||||
| CC | 64 (5.52) | 41 (3.07) | 1.78 (1.19–2.67) | 0.0050 | 1.83 (1.22–2.75) | 0.0033 | ||||
| C allele frequency | 458 (19.74) | 502 (18.79) | 0.3937 | |||||||
| CT/CC vs. TT (dominant model) | 0.98 (0.83–1.15) | 0.7766 | 0.98 (0.83–1.16) | 0.8013 | ||||||
| CC vs. CT/TT (recessive model) | 1.84 (1.24–2.75) | 0.0027 | 1.89 (1.27–2.83) | 0.0018 | ||||||
| rs4533622 CTNNB1 | CC | 725 (62.50) | 817 (61.15) | 0.6557 | 0.6748 | Reference | Reference | |||
| AC | 366 (31.55) | 444 (33.23) | 0.93 (0.78–1.10) | 0.3979 | 0.93 (0.78–1.10) | 0.3890 | ||||
| AA | 69 (5.95) | 75 (5.61) | 1.04 (0.74–1.46) | 0.8357 | 1.05 (0.74–1.47) | 0.7940 | ||||
| A allele frequency | 504 (21.72) | 594 (22.23) | 0.6666 | |||||||
| AC/AA vs. CC (dominant model) | 0.95 (0.80–1.11) | 0.4899 | 0.95 (0.80–1.11) | 0.4922 | ||||||
| AA vs. AC/CC (recessive model) | 1.60 (0.76–1.49) | 0.7203 | 1.07 (0.79–1.51) | 0.6781 | ||||||
| rs4135385 CTNNB1 | GG | 295 (25.43) | 356 (26.65) | 0.7748 | 0.6438 | Reference | Reference | |||
| AG | 601 (51.81) | 677 (50.67) | 1.07 (0.89–1.30) | 0.4765 | 1.08 (0.89–1.31) | 0.4318 | ||||
| AA | 264 (22.76) | 303 (22.68) | 1.05 (0.84–1.32) | 0.6639 | 1.06 (0.85–1.33) | 0.5947 | ||||
| A allele frequency | 1129 (48.66) | 1283 (48.02) | 0.6480 | |||||||
| AG/AA vs. GG (dominant model) | 1.07 (0.89–1.27) | 0.4908 | 1.07 (0.90–1.29) | 0.4350 | ||||||
| AA vs. AG/GG (recessive model) | 1.01 (0.83–1.21) | 0.9625 | 1.01 (0.84–1.22) | 0.9098 | ||||||
| rs2293303 CTNNB1 | CC | 879 (75.78) | 1048 (78.44) | 0.0629 | 0.0444 | Reference | Reference | |||
| TC | 251 (21.64) | 269 (20.13) | 1.11 (0.92–1.35) | 0.2814 | 1.11 (0.91–1.35) | 0.2961 | ||||
| TT | 30 (2.59) | 19 (1.42) | 1.88 (1.05–3.37) | 0.0330 | 1.92 (1.07–3.43) | 0.0288 | ||||
| T allele frequency | 311 (13.41) | 307 (11.49) | 0.0404 | |||||||
| TC/TT vs. CC (dominant model) | 1.16 (0.97–1.40) | 0.1133 | 1.16 (0.97–1.40) | 0.1113 | ||||||
| TT vs. TC/CC (recessive model) | 1.94 (1.08–3.51) | 0.0272 | 1.97 (1.09–3.55) | 0.0246 |
a Two-sided χ2 test for difference in frequency distribution of genotypes between cases and controls.
b Two-sided χ2 test for difference in frequency distribution of alleles between cases and controls.
c Adjusted for age at menarche, age of first birth and family history of cancer in first-degree relatives.
Bold numbers indicate a statistical significance at 0.05 level.