Table 5. Risk of breast cancer associated with the combination of susceptible SNPs and menarche-FFTP interval.
| Menarche-FFTP interval ≤11 years | Menarche-FFTP interval > 11 years | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | SNP/Genotype | Case /Control | aOR (95% CI) a | P a | Case/Control | aOR (95% CI) a | P a | |
| CDH1 | rs7200690 | CC+CT | 479/808 | Reference | 600/466 | 2.18 (1.85–2.57) | <.0001 | |
| TT | 32/35 | 1.55 (0.95–2.53) | 0.0818 | 49/27 | 3.07 (1.90–4.98) | <.0001 | ||
| rs7198799 | CC+CT | 495/824 | Reference | 618/481 | 2.15 (1.82–2.53) | <.0001 | ||
| TT | 16/19 | 1.41 (0.72–2.76) | 0.3205 | 31/12 | 4.31 (2.20–8.48) | <.0001 | ||
| rs17715799 | AA+AT | 483/803 | Reference | 600/472 | 2.12 (1.80–2.50) | <.0001 | ||
| TT | 28/40 | 1.17 (0.71–1.92) | 0.5381 | 49/21 | 3.89 (2.31–6.57) | <.0001 | ||
| rs13689 | TT+CT | 478/816 | Reference | 618/479 | 2.21 (1.88–2.61) | <.0001 | ||
| CC | 33/27 | 2.10 (1.24–3.53) | 0.0054 | 31/14 | 3.80 (2.00–7.21) | <.0001 | ||
| CTNNB1 | rs2293303 | CC+TC | 498/832 | Reference | 632/486 | 2.18 (1.86–2.57) | <.0001 | |
| TT | 13/11 | 1.98 (0.88–4.46) | 0.0980 | 17/7 | 4.07 (1.68–9.87) | 0.0019 | ||
a Adjusted for family history of cancer in first-degree relatives. Bold numbers indicate a statistical significance at 0.05 level.