Table 1. Model parameter values.

Parameter	Description	Values	Notes and Refs
r N	Radius of neurofilament backbone	5 nm	[3, 107, 108]
r M	Radius of microtubule backbone	12.5 nm	[3]
r M	Radius of organelles	25–200 nm	[50, 109] E.E.
R b	capturing radius for microtubule-cargoe active binding	80 nm	[110]
$k_{on}^N$	rate for neurofilament binding	1.0 × 10−2 /s	[111], E.E.
$k_{off}^N$	rate for neurofilament unbinding	6.5 × 10−2 /s	[111]
$k_{out}^N$	rate for neurofilament departure	0.1 /s	E.E
$k_{on}^O$	rate for organelle binding	2 /s	[112, 113]
$k_{off}^O$	rate for organelle unbinding	2 /s	[112]
$k_{in}^O$	rate for organelle passage	0.105 /s	[50, 109], E.E.
s O	speed of organelle movement along microtubules	1 μm/s	[114]
L r	characteristic repulsion distance	121.2 nm	[102], E.E.
ε r	repulsion scale (= ε NN)	0.5 pN	E.E.
κ N	effective spring constant for microtubule-neurofilament binding	0.18 pN/nm	[115], E.E.
κ O	effective spring constant for organelle-microtubule binding	0.9 pN/nm	[115], E.E.
μ N	drag coefficient of neurofilaments	73.5 pN ⋅ s/μm	E.E
μ M	drag coefficient of microtubules	512 pN ⋅ s/μm	E.E
μ O	drag coefficient of organelles	40.3 pN ⋅ s/μm	E.E
D N	diffusion coefficient of neurofilaments	5.59 × 10−5 μm2/s	E.E.
D M	diffusion coefficient of microtubules	8.02 × 10−6 μm2/s	E.E.
D F	diffusion coefficient of organelles	1.02 × 10−4 μm2/s	E.E.

E.E.: estimated from experiments; see S1 Text for detailed information.