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. 2015 Aug 18;11(8):e1005100. doi: 10.1371/journal.ppat.1005100

Fig 4. Application of optimized protocol to in vivo titrations.

Fig 4

The procedure outlined in Fig 2 was used to titrate two different SIV strains in vivo. For both strains, challenges and outcomes are represented pictorially, with statistical analyses tabulated to the right. Estimates of AID50 and its precision were done using the first order kinetics model described in Fig 1 (“FOK”), or by the Logit model online calculator (“Logit”) [25]. (A) Titration of SIV FL14-TR. (B) Titration of SIV FL14-AK. Note that the protocol was terminated with one animal still uninfected in phase 2; further challenges will not substantively change the estimate of AID50.